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61.
For linear compartment models or Leslie-type staged population models with quasi-positive matrix the spectral bound of the matrix (the eigenvalue determining stability) is studied in the situation where particles or individuals leave a compartment or stage with some rate and enter another with the same rate. Then the matrix carries the rate with a positive sign in some off-diagonal entry and with a negative sign in the corresponding diagonal entry. Hence the matrix does not depend on the rate in a monotone way. It is shown, however, that the spectral bound is a monotone function of the rate. It is all the time strictly increasing or strictly decreasing or it is constant. A simple algebraic criterion distinguishes between the three cases. The results can be applied to linear systems and to the stability of stationary states in non-linear systems, in particular to models for the transmission of infectious diseases, and in population dynamics. 相似文献
62.
The study of nocturnal bird migration by cone methods of observation has a century-long history but has continued to be used up to the present. To describe the flux and estimate the number of passing birds a probabilistic model is proposed. This model is based on the concept of dynamic Poisson ensemble of points in appropriate phase space and has two parameters. One is scalar and the other one is functional. We constructed consistent estimations of these parameters and discuss their use for the numerical estimation of the flux of birds observed in a narrow light cone generated by the bright lunar disk and formed by an open angle of telescope. Selection on the same type of birds was suggested as the necessary condition for the model application. Ground speed of each bird was introduced into the model as a new but obligatory value determining the quantification of the flux of bird. 相似文献
63.
In vivo functions of mitogen-activated protein kinases: conclusions from knock-in and knock-out mice 总被引:4,自引:0,他引:4
Multicellular organisms achieve intercellular communication by means of signalling molecules whose effect on the target cell
is mediated by signal transduction pathways. Such pathways relay, amplify and integrate signals to elicit appropriate biological
responses. Protein kinases form crucial intermediate components of numerous signalling pathways. One group of protein kinases,
the mitogen-activated protein kinases (MAP kinases) are kinases involved in signalling pathways that respond primarily to
mitogens and stress stimuli. In vitro studies revealed that the MAP kinases are implicated in several cellular processes,
including cell division, differentiation, cell survival/apoptosis, gene expression, motility and metabolism. As such, dysfunction
of specific MAP kinases is associated with diseases such as cancer and immunological disorders. However, the genuine in vivo
functions of many MAP kinases remain elusive. Genetically modified mouse models deficient in a specific MAP kinase or expressing
a constitutive active or a dominant negative variant of a particular MAP kinase offer valuable tools for elucidating the biological
role of these protein kinases. In this review, we focus on the current status of MAP kinase knock-in and knock-out mouse models
and their phenotypes. Moreover, examples of the application of MAP kinase transgenic mice for validating therapeutic properties
of specific MAP kinase inhibitors, and for investigating the role of MAP kinase in pathogen-host interactions will be discussed. 相似文献
64.
Wadley L 《Journal of human evolution》2007,52(6):681-689
Sibudu Cave in KwaZulu-Natal, South Africa, has a long Middle Stone Age (MSA) sequence with good organic preservation. The uppermost MSA sequence includes industries attributed to the final and late MSA and the Howiesons Poort. Below the Howiesons Poort are two layers containing some thin, bifacial lanceolate points, mostly in the form of distal and proximal fragments. These double-pointed foliates are the fossile directeur of the Still Bay Industry, and importantly, this Sibudu industry provides confirmation that the Still Bay predates the Howiesons Poort Industry. Technologically, the points from Sibudu are comparable to those from other South African sites with Still Bay occurrences (e.g., Blombos Cave and Hollow Rock Shelter). Although dating of the Sibudu Still Bay is preliminary, its age falls within the range of that at Blombos. For the past two decades, archaeologists have rejected the idea of a Still Bay Industry occurring outside of the Western Cape, but the Still Bay at Sibudu shows that this industry was, indeed, geographically widespread. 相似文献
65.
66.
Cryptic colour patterns in prey are classical examples of adaptations to avoid predation, but we still know little about behaviours that reinforce the match between animal body and the background. For example, moths avoid predators by matching their colour patterns with the background. Active choice of a species‐specific body orientation has been suggested as an important function of body positioning behaviour performed by moths after landing on the bark. However, the contribution of this behaviour to moths’ crypticity has not been directly measured. From observations of geometrid moths, Hypomecis roboraria and Jankowskia fuscaria, we determined that the positioning behaviour, which consists of walking and turning the body while repeatedly lifting and lowering the wings, resulted in new resting spots and body orientations in J. fuscaria and in new resting spots in H. roboraria. The body positioning behaviour of the two species significantly decreased the probability of visual detection by humans, who viewed photographs of the moths taken before and after the positioning behaviour. This implies that body positioning significantly increases the camouflage effect provided by moth’s cryptic colour pattern regardless of whether the behaviour involves a new body orientation or not. Our study demonstrates that the evolution of morphological adaptations, such as colour pattern of moths, cannot be fully understood without taking into account a behavioural phenotype that coevolved with the morphology for increasing the adaptive value of the morphological trait. 相似文献
67.
Success of embryo transfer is often a limiting factor in transgenic procedures and rederivation efforts, and depends on the genetic background of the donor and recipient strains used. Here we show that embryo transfer to DBA/2J females is possible, and present data on pre- and postnatal success rates after reciprocal embryo transfer using the inbred DBA/2J and C3H/HeN, and outbred NMRI strains. The highest embryo yield was achieved in outbred NMRI females, but embryo yields were similar in DBA/2J and C3H/HeN mice following superovulation despite poor estrus cycle synchronization in DBA/2J females. In-strain transfer of DBA/2J blastocysts (transfer of embryos to recipients from the same strain) resulted in pregnancy rates (57.1%) similar to those obtained following in-strain transfer of C3H/HeN (60.0%) and NMRI mice (83.3%), although the prenatal survival rate of blastocysts was low. Moreover, from the pups born only half survived the postnatal period after transfer of DBA/2J and C3H/HeN blastocysts to DBA/2J recipients. These problems were not observed when transferring NMRI-blastocysts to C3H/HeN and DBA/2J mothers. The number of blastocysts transferred also had a positive effect on the success of embryo transfer. In conclusion, C3H/HeN and DBA/2J females can be used as recipients for embryo transfer procedures for certain donor strains like NMRI, as one major determinant seems to be the genetic background of the embryos transferred. We also recommend to increase the number of DBA/2J blastocysts transferred, and to foster the DBA/2J pups to other DBA/2J mothers postnatally for in-strain transfer of DBA/2J mice. 相似文献
68.
K. Fechler D. Holtkamp G. Neusel J. I. Sanguinetti‐Scheck R. Budelli G. von der Emde 《Journal of fish biology》2012,81(7):2255-2276
In a food‐rewarded two‐alternative forced‐choice procedure, it was determined how well the weakly electric elephantnose fish Gnathonemus petersii can sense gaps between two objects, some of which were placed in front of complex backgrounds. The results show that at close distances, G. petersii is able to detect gaps between two small metal cubes (2 cm × 2 cm × 2 cm) down to a width of c. 1·5 mm. When larger objects (3 cm × 3 cm × 3 cm) were used, gaps with a width of 2–3 mm could still be detected. Discrimination performance was better (c. 1 mm gap size) when the objects were placed in front of a moving background consisting of plastic stripes or plant leaves, indicating that movement in the environment plays an important role for object identification. In addition, the smallest gap size that could be detected at increasing distances was determined. A linear relationship between object distance and gap size existed. Minimal detectable gap sizes increased from c. 1·5 mm at a distance of 1 cm, to 20 mm at a distance of 7 cm. Measurements and simulations of the electric stimuli occurring during gap detection revealed that the electric images of two close objects influence each other and superimpose. A large gap of 20 mm between two objects induced two clearly separated peaks in the electric image, while a 2 mm gap caused just a slight indentation in the image. Therefore, the fusion of electric images limits spatial resolution during active electrolocation. Relative movements either between the fish and the objects or between object and background might improve spatial resolution by accentuating the fine details of the electric images. 相似文献
69.
70.
在自然环境中,人和动物常在一定的背景噪声下感知信号声刺激,然而,关于低强度的弱背景噪声如何影响听皮层神经元对声刺激频率的编码尚不清楚.本研究以大鼠听皮层神经元的频率反应域为研究对象,测定了阈下背景噪声对79个神经元频率反应域的影响.结果表明,弱背景噪声对大鼠初级听皮层神经元的听反应既有抑制性影响、又有易化性影响.一般来说,抑制性影响使神经元的频率调谐范围和最佳频率反应域缩小,易化性影响使神经元的频率调谐范围和最佳频率反应域增大.对于少数神经元,弱背景噪声并未显著改变其频率调谐范围,但却改变了其最佳频率反应域范围.弱背景噪声对63.64%神经元的特征频率和55.84%神经元的最低阈值无显著影响.神经元频率调谐曲线的尖部比中部更容易受到弱背景噪声的影响.该研究结果有助于我们进一步理解复杂声环境下大脑听皮层对听觉信息的编码机制. 相似文献